# Source code for indra.explanation.model_checker.model_checker

```
import logging
import textwrap
import itertools
from collections import deque
from copy import deepcopy
import numpy as np
import networkx as nx
try:
import paths_graph as pg
has_pg = True
except ImportError:
has_pg = False
logger = logging.getLogger(__name__)
[docs]class PathMetric(object):
"""Describes results of simple path search (path existence).
Attributes
----------
source_node : str
The source node of the path
target_node : str
The target node of the path
length : int
The length of the path
"""
def __init__(self, source_node, target_node, length):
self.source_node = source_node
self.target_node = target_node
self.length = length
def __repr__(self):
return str(self)
def __str__(self):
return ('source_node: %s, target_node: %s, length: %d' %
(self.source_node, self.target_node, self.length))
[docs]class PathResult(object):
"""Describes results of running the ModelChecker on a single Statement.
Attributes
----------
path_found : bool
True if a path was found, False otherwise.
result_code : string
- *STATEMENT_TYPE_NOT_HANDLED* - The provided statement type is not
handled
- *SUBJECT_MONOMERS_NOT_FOUND* or *SUBJECT_NOT_FOUND* -
Statement subject not found in model
- *OBSERVABLES_NOT_FOUND* or *OBJECT_NOT_FOUND* -
Statement has no associated observable
- *NO_PATHS_FOUND* - Statement has no path for any observable
- *MAX_PATH_LENGTH_EXCEEDED* - Statement has no path len <=
MAX_PATH_LENGTH
- *PATHS_FOUND* - Statement has path len <= MAX_PATH_LENGTH
- *INPUT_RULES_NOT_FOUND* - No rules with Statement subject found
- *MAX_PATHS_ZERO* - Path found but MAX_PATHS is set to zero
max_paths : int
The maximum number of specific paths to return for each Statement
to be explained.
max_path_length : int
The maximum length of specific paths to return.
path_metrics : list[:py:class:`indra.explanation.model_checker.PathMetric`]
A list of PathMetric objects, each describing the results of a simple
path search (path existence).
paths : list[list[tuple[str, int]]]
A list of paths obtained from path finding. Each path is a list of
tuples (which are edges in the path), with the first element of the
tuple the name of a rule, and the second element its polarity in the
path.
"""
def __init__(self, path_found, result_code, max_paths, max_path_length):
self.path_found = path_found
self.result_code = result_code
self.max_paths = max_paths
self.max_path_length = max_path_length
self.path_metrics = []
self.paths = []
def add_path(self, path):
self.paths.append(path)
def add_metric(self, path_metric):
self.path_metrics.append(path_metric)
def __str__(self):
summary = textwrap.dedent("""
PathResult:
path_found: {path_found}
result_code: {result_code}
path_metrics: {path_metrics}
paths: {paths}
max_paths: {max_paths}
max_path_length: {max_path_length}""")
ws = '\n '
# String representation of path metrics
if not self.path_metrics:
pm_str = str(self.path_metrics)
else:
pm_str = ws + ws.join(['%d: %s' % (pm_ix, pm) for pm_ix, pm in
enumerate(self.path_metrics)])
def format_path(path, num_spaces=11):
path_ws = '\n' + (' ' * num_spaces)
return path_ws.join([str(p) for p in path])
# String representation of paths
if not self.paths:
path_str = str(self.paths)
else:
path_str = ws + ws.join(['%d: %s' % (p_ix, format_path(p))
for p_ix, p in enumerate(self.paths)])
return summary.format(path_found=self.path_found,
result_code=self.result_code,
max_paths=self.max_paths,
max_path_length=self.max_path_length,
path_metrics=pm_str, paths=path_str)
def __repr__(self):
return str(self)
[docs]class ModelChecker(object):
"""The parent class of all ModelCheckers.
Parameters
----------
model : pysb.Model or indra.assemblers.indranet.IndraNet or PyBEL.Model
Depending on the ModelChecker class, can be different type.
statements : Optional[list[indra.statements.Statement]]
A list of INDRA Statements to check the model against.
do_sampling : bool
Whether to use breadth-first search or weighted sampling to
generate paths. Default is False (breadth-first search).
seed : int
Random seed for sampling (optional, default is None).
Attributes
----------
graph : nx.Digraph
A DiGraph with signed nodes to find paths in.
"""
def __init__(self, model, statements=None, do_sampling=False, seed=None):
self.model = model
if statements:
self.statements = statements
else:
self.statements = []
if seed is not None:
np.random.seed(seed)
# Whether to do sampling
self.do_sampling = do_sampling
self.graph = None
[docs] def add_statements(self, stmts):
"""Add to the list of statements to check against the model.
Parameters
----------
stmts : list[indra.statements.Statement]
The list of Statements to be added for checking.
"""
self.statements += stmts
[docs] def check_model(self, max_paths=1, max_path_length=5):
"""Check all the statements added to the ModelChecker.
Parameters
----------
max_paths : Optional[int]
The maximum number of specific paths to return for each Statement
to be explained. Default: 1
max_path_length : Optional[int]
The maximum length of specific paths to return. Default: 5
Returns
-------
list of (Statement, PathResult)
Each tuple contains the Statement checked against the model and
a PathResult object describing the results of model checking.
"""
results = []
for idx, stmt in enumerate(self.statements):
logger.info('---')
logger.info('Checking statement (%d/%d): %s' %
(idx + 1, len(self.statements), stmt))
result = self.check_statement(stmt, max_paths, max_path_length)
results.append((stmt, result))
return results
[docs] def check_statement(self, stmt, max_paths=1, max_path_length=5):
"""Check a single Statement against the model.
Parameters
----------
stmt : indra.statements.Statement
The Statement to check.
max_paths : Optional[int]
The maximum number of specific paths to return for each Statement
to be explained. Default: 1
max_path_length : Optional[int]
The maximum length of specific paths to return. Default: 5
Returns
-------
result : indra.explanation.modelchecker.PathResult
A PathResult object containing the result of a test.
"""
# Make sure graph is created
self.get_graph()
# Extract subject and object info from test statement
subj_list, obj_list, result_code = self.process_statement(stmt)
if result_code:
return self.make_false_result(result_code, max_paths,
max_path_length)
for subj, obj in itertools.product(subj_list, obj_list):
result = self.find_paths(subj, obj, max_paths, max_path_length)
# If a path was found, then we return it; otherwise, that means
# there was no path for this object, so we have to try the next
# one
if result.path_found:
logger.info('Found paths for %s' % stmt)
return result
# If we got here, then there was no path for any observable
logger.info('No paths found for %s' % stmt)
return self.make_false_result('NO_PATHS_FOUND',
max_paths, max_path_length)
[docs] def find_paths(self, subj, obj, max_paths=1, max_path_length=5):
"""Check for a source/target path in the model.
Parameters
----------
subj : pysb.MonomerPattern or tuple
Relevant to the model information about the subject of the
Statement being checked (monomer pattern in PySB, source node for
other models).
obj : tuple
Tuple representing the target node (created from PySB model
Observable, PyBEL node, or Agent.name with a target sign).
max_paths : int
The maximum number of specific paths to return.
max_path_length : int
The maximum length of specific paths to return.
Returns
-------
PathResult
PathResult object indicating the results of the attempt to find
a path.
"""
# Get the input set (signed rules or names for source nodes)
input_set, result_code = self.process_subject(subj)
if result_code:
return self.make_false_result(result_code,
max_paths, max_path_length)
# # -- Route to the path sampling function --
# NOTE this is not generic at this point!
# if self.do_sampling:
# if not has_pg:
# raise Exception('The paths_graph package could not be '
# 'imported.')
# return self._sample_paths(input_set, obj, target_polarity,
# max_paths, max_path_length)
# -- Do Breadth-First Enumeration --
# Generate the predecessors to our observable and count the paths
path_lengths = []
path_metrics = []
sources = []
for source, path_length in self._find_sources(obj, input_set):
pm = PathMetric(source, obj, path_length)
path_metrics.append(pm)
path_lengths.append(path_length)
# Keep unique sources but use a list (not set) to preserve order
if source not in sources:
sources.append(source)
logger.info('Finding paths between %s and %s' % (subj, obj))
# Now, look for paths
if path_metrics and max_paths == 0:
pr = PathResult(True, 'MAX_PATHS_ZERO',
max_paths, max_path_length)
pr.path_metrics = path_metrics
return pr
elif path_metrics:
if min(path_lengths) <= max_path_length:
pr = PathResult(True, 'PATHS_FOUND',
max_paths, max_path_length)
pr.path_metrics = path_metrics
# Get the first path
# Try to find paths of fixed length using sources found above
for source in sources:
path_iter = get_path_iter(self.graph, source, obj,
min(path_lengths))
for path in path_iter:
pr.add_path(tuple(path))
# Do not get next path if reached max_paths
if len(pr.paths) >= max_paths:
break
# Do not check next source if reached max_paths
if len(pr.paths) >= max_paths:
break
return pr
# There are no paths shorter than the max path length, so we
# don't bother trying to get them
else:
pr = PathResult(True, 'MAX_PATH_LENGTH_EXCEEDED',
max_paths, max_path_length)
pr.path_metrics = path_metrics
return pr
else:
return PathResult(False, 'NO_PATHS_FOUND',
max_paths, max_path_length)
def _find_sources(self, target, sources):
"""Get the subset of source nodes with paths to the target.
Given a target, a list of sources, and a path polarity, perform a
breadth-first search upstream from the target to determine whether
any of the queried sources have paths to the target with the
appropriate polarity. For efficiency, does not return the full path,
but identifies the upstream sources and the length of the path.
Parameters
----------
target : tuple
The node (object or rule name with a sign) in the graph to start
looking upstream for matching sources.
sources : list[tuple]
Signed nodes corresponding to the subject or upstream influence
being checked.
Returns
-------
generator of (source, path_length)
Yields tuples of source node (tuple of string and sign) and path
length (int). If there are no paths to any of the given source
nodes, the generator is empty.
"""
# First, create a list of visited nodes
# Adapted from
# networkx.algorithms.traversal.breadth_first_search.bfs_edges
visited = set([target])
# Generate list of predecessor nodes with a sign updated according to
# the sign of the target node
# The queue holds tuples of "parents" (in this case downstream nodes)
# and their "children" (in this case their upstream influencers)
queue = deque([(target, self.graph.predecessors(target), 0)])
while queue:
parent, children, path_length = queue[0]
try:
# Get the next child in the list
child = next(children)
# Is this child one of the source nodes we're looking for? If
# so, yield it along with path length.
# Also make sure that found source is positive
if (sources is None or child in sources) and child[1] == 0:
logger.debug("Found path to %s from %s with length %d"
% (target, child, path_length+1))
yield (child, path_length+1)
# Check this child against the visited list. If we haven't
# visited it already (accounting for the path to the node),
# then add it to the queue.
if child not in visited:
visited.add(child)
queue.append(
(child, self.graph.predecessors(child), path_length + 1))
# Once we've finished iterating over the children of the current
# node, pop the node off and go to the next one in the queue
except StopIteration:
queue.popleft()
# There was no path; this will produce an empty generator
return
def make_false_result(self, result_code, max_paths, max_path_length):
return PathResult(False, result_code, max_paths, max_path_length)
[docs] def get_graph(self, **kwargs):
"""Return a graph with signed nodes to find the path."""
raise NotImplementedError("Method must be implemented in child class.")
[docs] def process_statement(self, stmt):
"""
This method processes the test statement to get the data about subject
and object, according to the specific model requirements for model
checking, e.g. PysbModelChecker gets subject monomer patterns and
observables, while graph based ModelCheckers will return signed nodes
corresponding to subject and object. If any of the requirements are not
satisfied, result code is also returned to construct PathResult object.
Parameters
----------
stmt : indra.statements.Statement
A statement to process.
Returns
-------
subj_data : list or None
Data about statement subject to be used as source nodes.
obj_data : list or None
Data about statement object to be used as target nodes.
result_code : str or None
Result code to construct PathResult.
"""
raise NotImplementedError("Method must be implemented in child class.")
[docs] def process_subject(self, subj_data):
"""Processes the subject of the test statement and returns
the necessary information to check the statement. In case of
PysbModelChecker, method returns input_rule_set. If any of the
requirements are not satisfied, result code is also returned to
construct PathResult object.
"""
raise NotImplementedError("Method must be implemented in child class.")
def _sample_paths(self, input_set, obj_name, target_polarity,
max_paths=1, max_path_length=5):
raise NotImplementedError("Method must be implemented in child class.")
[docs]def get_path_iter(graph, source, target, path_length):
"""Return a generator of paths with path_length cutoff from source to target."""
# If source and target are the same node we need to find paths from source
# to its predecessors
if source == target:
new_targets = graph.predecessors(source)
for nt in new_targets:
path_iter = nx.all_simple_paths(graph, source, nt, path_length - 1)
try:
for p in path_iter:
path = deepcopy(p)
# Append source to close the loop
path.append(source)
yield path
except nx.NetworkXNoPath:
pass
else:
# Regular path search
path_iter = nx.all_simple_paths(graph, source, target, path_length)
try:
for path in path_iter:
yield path
except nx.NetworkXNoPath:
pass
[docs]def signed_edges_to_signed_nodes(graph, prune_nodes=True,
edge_signs={'pos': 0, 'neg': 1},
copy_edge_data=False):
"""Convert a graph with signed edges to a graph with signed nodes.
Each pair of nodes linked by an edge in an input graph are represented
as four nodes and two edges in the new graph. For example, an edge (a,
b, 0), where a and b are nodes and 0 is a sign of an edge (positive),
will be represented as edges ((a, 0), (b, 0)) and ((a, 1), (b, 1)),
where (a, 0), (a, 1), (b, 0), (b, 1) are signed nodes. An edge (a, b,
1) with sign 1 (negative) will be represented as edges ((a, 0), (b,
1)) and ((a, 1), (b, 0)).
Parameters
----------
graph : networkx.MultiDiGraph
Graph with signed edges to convert. Can have multiple edges between
a pair of nodes.
prune_nodes : Optional[bool]
If True, iteratively prunes negative (with sign 1) nodes without
predecessors.
edge_signs : dict
A dictionary representing the signing policy of incoming graph. The
dictionary should have strings 'pos' and 'neg' as keys and integers
as values.
copy_edge_data : bool|set(keys)
Option for copying edge data as well from graph. If False (default),
no edge data is copied (except sign). If True, all edge data is
copied. If a set of keys is provided, only the keys appearing in the
set will be copied, assuming the key is part of a nested dictionary.
Returns
-------
signed_nodes_graph : networkx.DiGraph
"""
signed_nodes_graph = nx.DiGraph()
nodes = []
for node, node_data in graph.nodes(data=True):
nodes.append(((node, 0), node_data))
nodes.append(((node, 1), node_data))
signed_nodes_graph.add_nodes_from(nodes)
edges = []
for u, v, edge_data in graph.edges(data=True):
copy_dict = deepcopy(edge_data)
edge_sign = copy_dict.pop('sign', None)
if edge_sign is None:
continue
edge_dict = copy_dict if copy_edge_data == True else \
({k: v for k, v in copy_dict.items() if k in copy_edge_data} if
isinstance(copy_edge_data, set) else {})
if edge_sign == edge_signs['pos']:
edges.append(((u, 0), (v, 0), edge_dict))
edges.append(((u, 1), (v, 1), edge_dict))
elif edge_sign == edge_signs['neg']:
edges.append(((u, 0), (v, 1), edge_dict))
edges.append(((u, 1), (v, 0), edge_dict))
signed_nodes_graph.add_edges_from(edges)
if prune_nodes:
signed_nodes_graph = prune_signed_nodes(signed_nodes_graph)
return signed_nodes_graph
[docs]def prune_signed_nodes(graph):
"""Prune nodes with sign (1) if they do not have predecessors."""
nodes_to_prune = [node for node, in_deg
in graph.in_degree()
if in_deg == 0 and node[1] == 1]
while nodes_to_prune:
graph.remove_nodes_from(nodes_to_prune)
# Make a list of nodes whose in degree is now 0
nodes_to_prune = [node for node, in_deg
in graph.in_degree()
if in_deg == 0 and node[1] == 1]
return graph
```